生物结构前沿学者讲坛第25讲

Transcription regulation in naive pluripotent stem cell specification and hematopoietic stem cell aging

报告人：

Dr. Yi Zhang, Fred Rosen Chair Professor, Harvard Medical School and Boston Children's Hospital. Investigator, Howard Hughes Medical Institute

主办单位：北京生物结构前沿研究中心

发布单位：生命学院

报告地点：生命科学馆143

报告时间：2024-10-29 10:30-12:00

主持人：颉伟教授和李海涛教授

Yi Zhang is a Fred Rosen Chair Professor of the Department of Genetics and Department of Pediatrics of the Harvard Medical School and Boston Children’s Hospital. His major interest has been the epigenetic basis of gene expression in embryonic development, stem cell reprogramming and aging, as well as reward-related brain learning and memory. He is also interested in how dysregulation of epigenetic enzymes contributes to various human diseases including cancer and drug addiction.

Dr. Zhang has made fundamental contributions to the epigenetics field through systematic identifying and characterizing chromatin modifying enzymes, including the nucleosome remodeling and deacetylase (NuRD) complex, histone methyltransferases (e.g. Ezh2/PRC2, Dot1L), the JmjC-containing histone demethylases, histone H2A ubiquitin E3 ligase PRC1, and the TET family of 5-methylcytosine dioxygenases. In addition to identifying these critical epigenetic enzymes, he contributed in elucidation the mechanisms underlying classic epigenetic phenomena, including Polycomb silencing, genomic imprinting, and X-chromosome inactivation. Furthermore, his lab has greatly improved the animal cloning technology by identifying and overcoming two of the most important epigenetic barriers of cloning, as well as helped in developing PRC2/EZH2 inhibitor tazemetostat, an FDA approved drug for epithliod sarcoma and follicular lymphoma. Dr. Zhang was named a Top 10 author of high impact papers in Genetics and Molecular Biology (2002-2006), and one of the most influential scientists in the world by ScienceWatch. He has published over 190 high impact papers with more than 90,000 citations and an H-index of 123.