姓  名:陆  韻
所在单位:环境生物学教研所
职  称:特聘研究员
办公电话:(86)-10-62796255
电子邮件:luyun@tsinghua.edu.cn
办公地点:北京海淀区清华大学环境节能楼724,100084

 

 


教育背景

1995.9-1999.7 清华大学生物科学与技术系 理学学士
1999.9-2005.1 清华大学生物科学与技术系 生物学博士

工作履历

2005.04-2009.07   美国杜克大学细胞生物学系 博士后(research associate)
2009.12-2016.12   清华大学环境环境学院 副教授
2017.01- 至今       清华大学环境环境学院 特聘研究员
                              
                                

学术兼职

钢铁工业环境保护国家重点实验室学术委员会委员

中国环境科学学会环境医学与健康分会会员

中国毒理学会环境与生态毒理专业委员会会员

日本水环境协会国际会员

研究领域

从毒理学的角度研究环境污染物与人类健康之间的关系。包括以基因组技术为基础的新的毒性检测和预测方法研究,以分子生物学和细胞生物学为基础的毒性机理研究,新兴有毒污染物的筛选,病原微生物检测,污染物(包括病原微生物)健康基准和标准的研究等。实验室致力于解决三个问题:什么污染物是有毒的?为什么有毒?多大量才有毒?

研究概况

1. 国家重点研发计划项目《再生水景观环境利用水质基准与风险控制技术》No. 2018YFC0406300, 3821万,联系人,课题《基于风险控制的水质基准与水质控制目标确定方法》No.2018YFC0406302,2018.7.1-2021.6.30,负责人.
2. 国家自然科学重点基金项目《再生水的生物风险产生机制与控制原理》,No.51738005,2018.1-2022.12,参与部分50万。
3. 国家科技重大专项项目《北京城市副中心高品质水生态建设综合示范项目》下子课题《北运河亲水景观水质安全性评价》,No. 2017ZX07103-004,2017.1-2020.6,主要参与人。
4. 国家自然科学基金面上项目《城市杂用再生水吸入暴露风险因子研究》,No. 21777084,2018.1-2021.12,项目负责人。
5. 国家重点研发计划项目,政府间国际科技创新合作重点专项《再生水安全供水系统与关键技术》,No. 2016YFE0118800,2016.12-2019.12,1675万,主要参与人。
6. 国家重点研发计划项目《京津冀水资源安全保障技术研发集成与示范应用》下课题《京津冀非常规水安全利用技术研发示范》,No. 2016YFC0401405,2016.7-2020.12,主要参与人。
7. 国家自然科学基金面上项目《再生水中新兴雌激素活性消毒副产物的亲和分离鉴定及其生成规律的研究》,No. 21377066, 2014.1-2017.12,项目负责人。
8. 国家高技术研究发展计划(863计划)《再生水的安全性评价与控制技术》,No. 2013AA065205, 2013.1-2015.12,主要参与人。
9. 清华大学自主科研青年教师自主选题基础研究项目,《基于雌激素受体致病机理的污染物筛选与鉴定》,2011.7-2014.6,项目负责人。
10. 环保部水专项(与中国环境科学研究院合作),《重点流域优控污染物水环境质量基准研究》,2012.1-2015.12,参与人。
11. 国家自然科学基金青年科学基金项目《MicroRNA毒理基因组学:雌激素在小鼠体内标准图谱的研究》,2011.1-2013.12,No. 21007030,项目负责人。
12. 教育部留学回国启动基金,《MicroRNA毒理基因组学标准图谱的研究》,2012.1-2012.12,项目负责人。
13. 日本松下公司合作项目,《碱性加氢饮用水胃保护功能研究》,2012.3-2012.12,项目负责人。

奖励与荣誉

1. 2018年,获2017年北京市高等教育教学成果奖一等奖,“多层次构建全球环境人才培养体系,全方位提升学生国际胜任力”,第9获奖人。
2. 2017年,JSWE-IDEA Water Environment International Exchange Award.
3. 2016年,获中国环境科学学会第十一届“优秀环境科技工作者奖”。
4. 2015年,获宝钢优秀教师奖。
5. 2014年,获中国环境保护部“国家环境保护专业技术青年拔尖人才”称号。
6. 2010年,获中国环境科学学会第七届“青年科技奖”。
7. 2003年,获教育部提名国家科学技术一等奖,第三完成人。

学术成果

部分论文:

[1] Xue J, Zhang J, Qiao J*, Lu Y*. Effects of chlorination and combined UV/Cl2 treatment on endotoxin activity and inhalation toxicity of lipopolysaccharide, gram-negative bacteria and reclaimed water. Water Research, 2019, 155:124-130.
[2] Ren Y, Kong J, Xue J, Shi X, Li H, Qiao J*, Lu Y*. Effects of ozonation on the activity of endotoxin and its inhalation toxicity in reclaimed water. Water Research, 2019, 154:153-161.
[3] Feng Y, Ren Z, Wu F, Reichert A, Lu Y*. Optimization of the gram staining method based on superparamagnetic magnetic nanobeads. Journal of Environmental Accounting and Management, 2018, 6(3):263-271.
[4] Yu T, Sun H, Chen Z, Wang Y-H, Huo Z-Y, Ikuno N, Ishii K, Jin Y, Hu H-Y, Wu Y-H*, Lu Y*. Different bacterial species and their extracellular polymeric substances (EPSs) significantly affected reverse osmosis (RO) membrane fouling potentials in wastewater reclamation. Science of the Total Environment, 2018, 644:486-493.
[5] Li G-Q, Huo Z-Y, Wu Q-Y, Lu Y*, Hu H-Y*. The synergistic effect of combined UV-LEDs and chlorine treatment on Bacillus Subtilis spores inactivation. Science of the Total Environment, 2018, 639:1233-1240.
[6] Xue J, Zhang J, Wu Q-Y*, Lu Y*. Sub-chronic inhalation of reclaimed water-induced fibrotic lesion in a mouse model. Water Research, 2018, 139:240-251.
[7] Chen Z, Yu T, Ngo HH, Lu Y, Li G, Wu Q, Li K, Bai Y, Liu S, Hu HY*. Assimilable organic carbon (AOC) variation in reclaimed water: Insight on biological stability evaluation and control for sustainable water reuse. Bioresource Technology, 2018, 254:290-299.
[8] Xu B, Li K, Qiao J, Liungai Z, Chen C*, Lu Y*. UV photoconversion of environmental oestrogen diethylstilbestrol and its persistence in surface water under sunlight. Water Research, 2017, 127:77-85.
[9] Li GQ; Wang WL; Huo ZY; Lu Y*; Hu HY*. Comparison of UV-LED and low pressure UV for water disinfection: photoreactivation and dark repair of Escherichia coli. Water Research, 2017, 126:134-143.
[10] Lv XT, Zhang X, Du Ye, Wu QY*, Lu Y*, Hu HY. Solar light irradiation significantly reduced cytotoxicity and disinfection byproducts in chlorinated reclaimed water. Water Research, 2017, 126:162-169.
[11] Li GQ, Yu T, Wu QY, Lu Y*, Hu HY*. Development of an ATP luminescence-based method for assimilable organic carbon determination in reclaimed water. Water Research, 2017, 123:345-352.
[12] Liu L, Zhou X*, Lu Y*, Shan D, Xu B, He M, Shi H, Qian Y. Facile screening of potential xenoestrogens by an estrogen receptor-based reusable optical biosensor. Biosensors and bioelectronics, 2017, 97:16-20.
[13] Wang WL, Wu QY*, Li ZM, Lu Y, Du Y, Wang T, Huang N, Hu HY*. Light-emitting diodes as an emerging UV source for UV/chlorine oxidation: Carbamazepine degradation and toxicity changes. Chemical Engineering Journal, 2017, 310:148-156.
[14] Du Y, Wu QY*, Lu Y, Hu HY*, Yang Y, Liu R, Liu F. Increase of cytotoxicity during wastewater chlorination: Impact factors and surrogates. Journal of Hazardous Materials, 2017, 324:681-690.
[15] Yu T, Meng L, Zhao Q-B, Shi Ye, Hu H-Y, Lu Y*. Effects of chemical cleaning on RO membrane inorganic, organic and microbial foulant removal in a full-scale plant for municipal wastewater reclamation. Water Research, 2017, 113:1-10.
[16] Yu T, Li GQ, Lin WQ, Hu H-Y, Lu Y*. Coagulation increased the growth potential of various species bacteria of the effluent of a MBR for the treatment of domestic wastewater. Environmental Science and Pollution Research, 2017, 24(6):5126-5133.
[17] Huo ZY, Xie X*, Yu T, Lu Y, Feng C, Hu HY*. Nanowire-Modified Three-Dimensional Electrode Enabling Low-Voltage Electroporation for Water Disinfection. Environmental Science & Technology, 2016, 50(14):7641-7649.
[18] Xue J, Zhang J, Xu B, Xie J, Wu W, Lu Y*. Endotoxins: the critical risk factor in reclaimed water via inhalation exposure. Environmental Science & Technology, 2016, 50:11957-11964.
[19] Duan R, Lu Y*, Hou L, Du L, Sun L, Tang X. U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen. Frontiers of Environmental Science & Engineering, 2016, 10(6):11.
[20] Li M, Xu B, Liungai Z, Hu H-Y, Qiao J*, Lu Y*. The removal of estrogenic activity with UV/chlorine technology and identification of novel estrogenic disinfection by-products. Journal of Hazardous Materials, 2016, 307:119-126.
[21] Zhang J, Xue J, Xu B, Xie J, Qiao J*, Lu Y*. Inhibition of Lipopolysaccharide Induced Acute Inflammation in Lung by Chlorination. Journal of Hazardous Materials, 2016, 303:131-136.
[22] Yang Y, Lu Y*, Wu QY, Hu H-Y*, Chen YH, Liu WL. Evidence of ATP assay as an appropriate alternative of MTT assay for cytotoxicity of secondary effluents from WWTPs. Ecotoxicology and Environmental Safety, 2015, 122:490-496.
[23] Shang G, Xue J, Li M, Hu H-Y, Lu Y*. Estrogen receptor affinity chromatography: a new method for characterization of novel estrogenic disinfection by-products. Chemosphere, 2014, 104:251-257.
[24] Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, Liu W, Lu Y*. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water, BMC Complementary and Alternative Medicine, 2014, 14:81.
[25] Wu Y-H, Hu H-Y*, Yu Y, Zhang T-Y, Zhu S-F, Zhuang L-L, Zhang X, Lu Y. Microalgal species for sustainable biomass/lipid production using wastewater as resource: A review. Renewable and Sustainable Energy Reviews, 2014, 33:675-688.
[26] Hou LY, Lu Y*, Li Y, Li L. MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus. Frontiers of Environmental Science and Engineering, 2014, 8(1):99-105.
[27] Liu KC, Jiang M, Lu Y, Chen H, Sun J, Wu SP, Ku WY, Nakagawa H, Kita Y, Natsugoe S, Peters JH, Rustgi AK, Onaitis MW, Kiernan A, Chen XX, Que JW*. Sox2 Cooperates with Inflammation-Mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells. Cell Stem Cell, 2013, 12(3):304-315.
[28] Xue J, Lu Y*, Velasquez N, Yu R-Z, Hu H-Y, Liu Z-T, Meng W. Introduction of risk size in the determination of uncertainty factor UFL in risk assessment. Environmental Research Letters, 2012, 7(3):034036. (IF 3.906)
[29] Xu, X; Rock, JR; Lu, Y; Futtner, C; Schwab, B; Guinney, J; Hogan, BLM; Onaitis, MW*. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. PNAS, 2012, 109(13): 4910-4915.
[30] Huang J-J, Hu H-Y*, Wu YH, Wei B, Lu Y. Effect of chlorination and ultraviolet disinfection on tetA-mediated tetracycline resistance of Escherichia coli. Chemosphere, 2012, 90(8):2247-2253.
[31] Huang J-J, Hu H-Y*, Lu SQ, Li Y, Tang F, Lu Y, Wei B. Monitoring and evaluation of antibiotic-resistant bacteria at a municipal wastewater treatment plant in China. Environmental International, 2012, 42:31-36.
[32] Huang J-J, Hu H-Y*, Tang F, Li Y, Lu SQ, Lu Y. Inactivation and reactivation of antibiotic-resistant bacteria by chlorination in secondary effluents of a municipal wastewater treatment plant. Water Research, 2011, 45(9):2775-2781.
[33] Lu Y, Futtner C, Rock JR, Xu X, Whitworth W, Hogan BLM, Onaitis MW*. Evidence That SOX2 Overexpression Is Oncogenic in the Lung. Plos One 2010;5:-.
[34] 陆韻*,侯凌燕,胡洪营,李莉。毒理基因组学研究进展。生态环境学报,2010,19(9):2232-2239.
[35] Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, Randell SH, Hogan BLM*. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proceedings of the National Academy of Sciences of the United States of America 2009;106:12771-12775.
[36] Erhunmwunsee L, Lu Y, Luo XY, Harpole DH, Hogan BLM, Onaitis MW*. Basal cells in lung cancer. Journal of the American college of surgeons, 2008, 207(3):S30-S30.
[37] Lu Y, Thomson JM, Wong HY, Hammond SM, Hogan BL*. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007 Oct 15;310(2):442-53. Epub 2007 Aug 9.
[38] Zhang G, Lu H, Lu Y, Jiang S, Chen YH*. Neutralization of HIV-1 primary isolate by ELDKWA-specific murine monoclonal antibodies. Immunobiology. 2005;210(9):639-45.
[39] Liu W, Zou P, Ding J, Lu Y, Chen YH*. Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design. Microbes Infect. 2005 Feb;7(2):171-7. Epub 2004 Dec 25.
[40] Liu W, Peng Z, Liu Z, Lu Y, Ding J, Chen YH*. High epitope density in a single recombinant protein molecule of the extracellular domain of influenza A virus M2 protein significantly enhances protective immunity. Vaccine. 2004 Dec 2;23(3):366-71.
[41] Lu Y, Chen YH*. Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region. Chinese Science Bulletin, 2003, 48(11):1115-1117
[42] Liu WL, Lu Y, Chen YH*. Bioinformatics analysis of SARS-CoV M protein provides information for vaccine development. Progress in Natural Science, 2003, 13(11):844-847
[43] Lu Y, Ding J, Liu WL, Chen YH*. A candidate vaccine against influenza virus intensively improved the immunogenicity of a neutralizing Epitope. International Archives of Allergy and Immunology, 2002, 127(3):245-250
[44] Lu Y, Ding J, Chen YH*. Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1. Immunopharmacology and Immunotoxicology, 2001, 23(4):487-494
[45] Xiao Y, Lu Y, Chen YH*.  Epitope-vaccine as a new strategy against HIV-1 mutation. Immunology Letters, 2001, 77:3-6
[46] Ding J, He F, Lu Y, Xiao Y, Chen YH*. Induction of multi-epitope-specific antibodies against HIV-1 by multi-epitope-vaccines. Chinese Science Bulletin, 2001, 46(22):1859-1864
[47] Yang HW, Xiao Y, Lu Y, Chen YH*. Characterization of interaction between C-domain on HIV-1 gp41 and the putative receptor protein p62. Immunobiology, 2001, 203(5):778-785
[48] Lu Y, Xiao Y, Ding J, Dierich MP, Chen YH*. Immunogenicity of neutralizing epitopes on multiple-epitope- vaccines against HIV-1. International Archives of Allergy and Immunology, 2000, 121(1):80-84
[49] Lu Y, Ding J, Xiao Y, Chen Y*. Multi-epitope-vaccines intensively increased levels of antibodies recognizing three neutralizing epitopes on HIV –1 envelop protein. Scandinavian Journal of Immunology, 2000, 51(5):497-501
[50] Liao MF, Lu Y, Xiao Y, Dierich MP, Chen YH*. Induction of high level of specific antibody response to the neutralizing epitope ELDKWA on HIV-1 gp41 by peptide-vaccine. Peptides, 2000, 21(4):463-468
[51] Ding J, Lu Y, Chen YH*. Candidate multi-epitope-vaccines in aluminium adjuvant induce high levels of antibodies with predefined multi-epitope-specificity against HIV-1. FEMS Immunology and Medical Microbiology 2000, 29(2):123-127
[52] Xiao Y, Liao MF, Lu Y, Dierich MP, Chen YH*. Epitope-vaccines:A new strategy to induce high levels of neutralizing antibodies against HIV-1. Immunobiology, 2000, 201(3-4):323-331
[53] Xiao Y, Zhao YX, Lu Y, Chen YH*. Epitope-vaccine induced high levels of ELDKWA-epitope-specific neutralizing antibody. Immunological Investigation, 2000, 29(1):41-50

获得专利
冯昱人,任滋禾,吴富华,陆韻,超顺磁性纳米磁珠革兰氏染色试剂盒。2018.6,中国,201810587523.9。
陆韻,商国栋,李曼,分离检测环境中雌激素类内分泌干扰物的方法,2015.2,中国,201310677352.6