Sen-Fang SUI

Academic Posts

Professor, School of Life Sciences, Tsinghua University
Member, Chinese Academy of Sciences
Member of the Editorial Board of Journal of Structural Biology (2000- ) and BBA Biomembranes (2005- )
Vice-president of the Chinese Electron Microscopy Society

Research Interests

  • Cryo-electron Microscopy of Protein Complexes and Macromolecular Machines
  • Structural and Molecular Biology of Membrane Proteins
  • Intracellular and Intercellular Vesicles Mediated Membrane Trafficking
  • Membrane Related Human Diseases

Professional Experiences

1989, Associate Professor of Tsinghua University
1991 to now, Professor of Tsinghua University


1988, Ph.D., Technical University Munich, Germany
1980, M.S., Tsinghua University, Beijing, China
1970, B.S., Tsinghua University, Beijing, China

Awards & Honors

2000, The First Prize of the Technological Achievement Award of Education Ministry
2001, PhD Candidate Supervisor of the National Excellent Doctoral Dissertation
2005, The Second Prize of the National Prize for Natural Sciences
2005, Membrane Molecular Biology, The Beijing Prize of Excellent Teaching Materials for Higher Education

Selected Publications

1. Q-T Shen, X-C Bai, L-F Chang, Yi Wu, Hong-Wei Wang, Sen-Fang Sui* (2009) Bowl-Shaped Oligomeric Structures on Membranes as DegP's new functional forms in Protein Quality Control. Proc. Natl. Acad. Sci. USA, 106(2009) 4858-4863.
2. Fan Zhang, Shan Sun, Du Feng, Wen-Long Zhao, Sen-Fang Sui* (2009) A novel Strategy for the Invasive Toxin: Hijacking Exosome-mediated Intercellular Trafficking. Traffic 10 (2009) 411-424.
3. Jiansen Jiang, X. Zhang, Y. Chen, Y. Wu, Z. H. Zhou, Zengyi Chang*, Sen-Fang Sui* (2008) Activation of DegP Chaperone-Protease via Formation of Large Cage-like Oligomers Upon Binding to Substrate Proteins. P. Natl. Acad. Sci. USA, 105(2008) 11939-11944.
4. Shan Sun, Feng Chen, Tong-Jin Zhao, Xiao-Hong Fang, Yi-Qoin Li, Sen-Fang Sui* (2008) TINY, a DREB-like Transcription Factor Connecting the DRE- and ERE-mediated Signaling Pathways in Arabidopsis. J. Biological Chemistry 283(2008)6261-6271.
5. Y Chen, X Pan, Y Tang, S Quan, P Tai, Sen-Fang Sui* (2008) Full length E.coli SecA dimerizes in a closed conformation in solution as determined by cryo- electron microscopy. J. Biological Chemistry 283(2008) 28783-28787.
6. Shi-Zhen Wang, Yong Chen, Zhan-Hua Sun, Qiang Zhou, Sen-Fang Sui* (2006) Escherichia coli CorA periplasmic domain function as homotetramer to bind substrate. J. Biological Chemistry, 281(2006) 26813-26820.
7. H.W.Wang, Y.Chen, H.Yang, X.Chen, M.X.Duan, P.C.Tai*, Sen-Fang Sui* (2003) Ring-like pore structures of SecA: Implication for bacterial protein-conducting channels. P. Natl. Acad. Sci. USA, 100(2003)4221-4226.
8. Yi Wu, Y.H. He, J.Bai, S.R.Ji, W.C,Tucker, E.R.Chapman*, Sen-Fang Sui* (2003) Visualization of synaptotagmin I oligomers assembled onto lipid monolayers. P. Natl. Acad. Sci. USA, 100(2003)2082-2087.
9. Shang-Rong Ji, Yi Wu and Sen-fang Sui* (2002) Cholesterol is an important factor affecting the membrane insertion of b-amyloid peptide (Ab1-40),which may potionally inhibit the fibril formation. J. Biological Chemistry 277(2002)6273-6279.
10. Zhanfang Ma and Sen-fang Sui* (2002) Naked-Eye Sensitive Detection of Immunoglubulin G by Enlargement of Au-Nanoparticles in Vitro. Angewandte Chemie International Edition 41(2002)2176-2179.


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