RAO Zihe

Academic Posts

Professor of Structural Biology
Member of the Chinese Academy of Sciences (CAS)
Member of the Third World Academy of Science
President of the Biophysical Society of China
Executive council member of the International Union for Pure and Applied Biophysics (IUPAB)
Executive member of the International Organization for Biological Crystallography (IOBC)

Research Interests

  • The structure, function and drug discovery of important virus and tumor related proteins.


1989-1992 (Molecular Biophysics with David Stuart FRS)
Post-doctoral Researcher in Laboratory of Molecular Biophysics, Oxford University
1985 - 1989 Ph.D. (Protein Crystallography with Neil Isaacs FRSE)
St.Vincent's Institute of Medical Research & Department of Biochemistry, Melbourne University, Australia
1979 - 1982 M.Sc. (Protein Crystallography with Dong-Cai Liang MCAS)University of Science & Technology of China (USTC) & Institute of Biophysics, Chinese Academy of Sciences
1973 - 1977 B.Sc. (Biophysics)
University of Science & Technology of China (USTC), Chinese Academy of Sciences

Awards & Honors

1999: Qiushi Outstanding Scientist Prize in Life Sciences
1999: Yangtze River Distinguished Scholar Professor, Ministry of Education
2003: He Liang He Li Foundation Science and Technology Prize
2006: Chen Jiageng Prize for Life Science
2006: Trieste Science Prize for Medical Science

Selected Publications

Published more than 180 peer-reviewed papers in international scientific journals such as Cell, Nature, PLoS Biology, Nat. Struct. & Mol. Biol., PNAS, Curr. Opin. Struct. Biol., J. Biol. Chem., J. Mol. Biol., J. Virology, Structure, Curr.Pharm. Design, J. Am. Chem. Soc. and so on.
1. Liu Z, Lin H, Ye S, Liu Q, Meng Z, Zhang C, Xia Y, Margoliash E* & Rao Z* & Liu X*. 2006. Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. Proc. Natl. Acad. Sci. USA,103(24): 8965-8970
2. Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M & Rao Z*. 2005. Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex Ⅱ. Cell, 121: 1043-1057
3. Yang H, Xie WQ, Xue XY, Yang KL, Ma J, Liang WX, Zhao Q, Zhou Z, Pei DQ, J. Ziebuhr, R. Hilgenfeld, K. Y. Yuen, Wong L., Gao GX, Chen SJ, Chen Z, Ma DW, Bartlam M & Rao Z*. 2005. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biology, 3(10):e324, 1742-1752
4. Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, & Rao Z*. 2005. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric nsp7•nsp8 super-complex. Nature Structural & Molecular Biology, 12(11): 980-986
5. Xu F, Bell SG, Lednik J, Insley A, Rao Z* & Wong L*. 2005. The Heme Monooxygenase Cytochrome P450cam Can Be Engineered to Oxidize Ethane to Ethanol. Angew Chem Int Ed Engl., 44(26):4029-4032
6. Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B & Rao Z*. 2004. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci USA., 101(22):8348-8353
7. Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y & Rao Z*. 2004. Crystal Structure of an Acylpeptide Hydrolase/Esterase from Aeropyrum pernix K1. Structure, 12(8):1481-1488
8. Bell S.G, Chen X, Sowden R.J, Xu F, Williams J.N, Wong L* & Rao Z*. 2003. Molecular Recognition in (+)-alpha-Pinene Oxidation by Cytochrome P450(cam). J Am Chem Soc., 125(3): 705-714
9. Rao Z, Belyaev A, Fry E, Jones I, Roy P&Stuart D. 1995. Crystal Structure of SIV Matrix Antigen and its Implications for Virus Assembly. Nature,378(6558): 743-747
10. Rao Z, Handford P, Mayhew M, Knott V, Brownlee G&Stuart D. 1995. The Structure of a Calcium Binding Epidermal Growth Factor-like Domain - its Role in Protein-Protein Interactions. Cell, 82(1): 131-141


• Address at Nankai University:-94 Weijin Road, Nankai District, Tianjin 300071, China
Tel: +86 22 23501631 (O) Fax: +86 22 23501631
E-mail: raozh@nankai.edu.cn
• Address at Tsinghua University:-Laboratory of Structural Biology, Life Sciences Building, Tsinghua University, Beijing 100084, China
Tel: +86 10 62771493 (O) Fax: +86 10 62773145
E-mail: raozh@xtal.tsinghua.edu.cn Web: www.xtal.tsinghua.edu.cn