清华大学材料学院

                                       School of Materials Science and Engineering

王秀梅

王秀梅,研究员,清华大学逸夫技术科学楼B804房间,010-62782966,13911045271,wxm@mail.tsinghua.edu.cn

个人主页:MSE/wangxiumei

教育背景

09/2000-01/2005: 工学博士,清华大学,材料物理与化学专业
09/1996-07/2000: 工学学士,清华大学,材料科学与工程专业

工作履历

12/2013至今:研究员,博士生导师,清华大学材料学院
01/2009-12/2013: 副研究员,清华大学材料学院
01/2008-12/2008: 讲师,清华大学材料科学与工程系
05/2006-01/2008: 博士后,美国麻省理工学院(MIT),生物医学工程中心 (Center for Biomedical Engineering)
07/2005-05/2006: 博士后,美国罗切斯特大学医学院(University of Rochester Medical Center),骨科研究中心 (Center for Musculoskeletal Research)

学术兼职

Editor, SCI国际期刊Frontier of Materials Science
Regional Editor of Asia, 国际期刊Current Tissue Engineering
Managing Editor, 国际期刊Regenerative Biomaterials
中国生物材料学会,常务理事
中国生物材料学会神经修复材料与植入器械分会,副主任委员
中国生物材料学会青年委员会,委员
中国生物材料学会骨修复材料与器械分会,委员
中国生物材料学会再生医学材料分会,委员
中国材料研究会青年工作委员会,常务理事
中国材料研究会外事工作委员会,委员
中国硅酸盐学会特种陶瓷分会理事
中国机械工程学会表面工程分会生物材料表面工程专委会委员
中国医师协会骨科医师分会骨科技术创新与转化工作委员会委员
中国研究型医院学会技术创新与转化分会骨科生物材料与内置物学组委员
全国外科植入物和矫形器械标准化技术委员会组织工程医疗器械产品分技术委员会骨再生标准工作组专家
中国抗衰老促进会交叉学科专业委员会委员

研究领域

生物材料、组织工程与再生医学

研究概况

主要从事生物材料基础研究及生物医用材料产品开发,主要包括材料调控干细胞功能、诱导血管化生物材料、颅骨再生修复、神经组织再生修复材料的开发及临床转化。

奖励与荣誉

2011年国家自然科学二等奖(2011-Z-108-2-03);项目名称:生物矿化纤维的分级组装机理研究;完成人:崔福斋、王秀梅、李恒德、蔡强、孔祥东
2011年度中华医学科技奖三等奖 (201103069U0201);项目名称:用组织工程技术修复中枢神经系统损伤的实验研究;完成人:徐群渊,崔福斋,王颖,王秀梅,田维明,魏岳腾,任永娟,马军
2014年山东省科技进步一等奖;项目名称:带肋间神经的肋骨肌皮瓣移植修复下颌骨缺损的基础研究与临床应用;完成人:张彬;朱国雄;谭颖徽;王秀梅;赵华强等。
2010年北京市科学技术奖二等奖 (2010材-2-004);项目名称:生物矿化纤维的分级组装机理研究;完成人:崔福斋、王秀梅、李恒德、蔡强、孔祥东
2012 年度清华大学“学术新人奖”
入选2013 年度教育部“新世纪优秀人才”支持计划
第12届霍英东教育基金会青年基金奖(霍英东教育基金会)
2016宝钢优秀教师奖(宝钢教育基金会)
2016清华大学“刘冰奖”(清华大学)

学术成果

近期论文(及专利)
1.Zhang ZX, Yao SL, Xie S*, Wang XM*, Chang FY, Luo J, Wang JM, Fu J. Effect of hierarchically aligned fibrin hydrogel in regeneration of spinal cord injury demonstrated by tractography: A pilot study. Scientific Report. Scientific Reports, 2017, 7, 40017.
2.Yao SL, Liu X, Yu SK, Wang XM*, et al. Co-effects of matrix low elasticity and aligned topography on stem cell neurogenic differentiation and rapid neurite outgrowth. Nanoscale, 2016, 8, 10252-10265.
3.Xu SJ, Qiu ZY, Wu JJ, Kong XD, Weng XS, Cui FZ*, Wang XM*. Osteogenic Differentiation Gene Expression Profiling of hMSCs on Hydroxyapatite and Mineralized Collagen. Tissue Engineering Part A. 2016; 22: 170-181.
4.Guan FY, Lu JJ, Wang XM*. A novel honeycomb cell assay kit designed for evaluating horizontal cell migration in response to functionalized self-assembling peptide hydrogels. Frontiers of Materials Science. 2017, 11(1):13-21.
5.Liu FZ, Wang DW, Zhang YJ, Lv ZY, Sun XD, Li KY, Zhang B*, Wang XM*, Cui FZ. Comparison of rabbit rib defect regeneration with and without graft. Journal of Materials Science-Materials in Medicine. 2017, 28(1): 10.1007/s10856-016-5807-1.
6.Liu FZ, Lv ZY, Zhang YJ, Li KY, Wang DW, Zhang B*, Wang XM*. Comparison of Rabbit Rib Defect Regeneration Implanted Mineralized Collagen With and Without Periosteum. Journal of Biomaterials and Tissue Engineering. 2017, 7(2): 134-138.
7.Yao SL, Liu X, He J, Wang XM*, Wang Y, and Cui FZ. Ordered self-assembled monolayers terminated with different chemical functional groups direct neural stem cell linage behaviours. Biomedical Materials. 2016, 11(1): 014107.
8.Zhou JF, Cheng L, Sun XD*, Wang XM*, Jin SH, Li JX, Wu Q. Neurogenic differentiation of human umbilical cord mesenchymal stem cells on aligned electrospun polypyrrole/polylactide composite nanofibers with electrical stimulation. Frontiers of Materials Science. 2016, 10(3): 260-269.
9.Meng QY, Tao CS, Qiu ZY, Akaike T, Cui FZ, Wang XM*. A hybrid substratum for primary hepatocyte culture that enhances hepatic functionality with low serum dependency. International Journal of Nanomedicine. 2015: 10, 2313-2323.
10.Qiu ZY, Cui Y, Tao CS, Zhang ZQ, Tang PF, Mao KY, Wang XM*, Cui FZ. Mineralized Collagen: Rationale, Current Status, and Clinical Applications. Materials 2015, 8(8), 4733-4750.
11.Liu X, Pi B, Wang H, Wang XM*. Self-assembling peptide nanofiber hydrogels for central nervous system regeneration. Frontiers of Materials Science. 2015, 9(1): 1-13.
12.Lian XJ*, Mao KZ, Liu X, Wang XM, and Cui FZ. In Vivo Osteogenesis of Vancomycin Loaded Nano-Hydroxyapatite /Collagen/ Calcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis. Journal of Nanomaterials. 2015. 261492.
13.Tao H, Wu YH, Li HF, Wang CF, Zhang Y, Li C, Wen TY, Wang XM, et al. BMP7-Based Functionalized Self-Assembling Peptides for Nucleus Pulposus Tissue Engineering. ACS Applied Materials & Interfaces. 2015. 7(31): 17076-17087.
14.Wang RH, Wang Q, Wang XM*, et al. Enhancement of nano-hydroxyapatite bonding to dentin through a collagen/calcium dual-affinitive peptide for dentinal tubule occlusion. Journal of Biomaterials Applications. 2014. 29 (2): 268-277.
15.Tao H, Zhang Y, Wang C, Zhang C, Wang XM, et al. Biological evaluation of human degenerated nucleus pulposus cells in functionalized self-assembling peptide nanofiber hydrogel scaffold. Tissue Eng Part A. 2014. 20(11-12): 1621-1631.
16.Xiao YY, Zhang WZ, Wang XM*, et al. Optimized Preparation of Thiolated Hyaluronic Acid Hydrogel with Controllable Degree of Substitution. Journal of Biomaterials and Tissue Engineering. 2014. 4(4): 281-287.
17.Meng QY, Yao SL, Wang XM*, Chen YY. RADA16: a self-assembly peptide hydrogel for the application in tissue regeneration. Journal of Biomaterials and Tissue Engineering. 2014, 4(12): 1019-1029.
18.Liu X, Wang XM*, Wang XJ, et al. Functionalized self-assembling peptide nanofiber hydrogels mimic stem cell niche to control human adipose stem cells behaviors in vitro. Acta Biomaterialia. 2013, 9, 6798-6805.
19.Yao SL, Wang XM*, Liu X, et al. Effects of ambient relative humidity and solvent properties on the electrospinning of pure hyaluronic acid nanofibers. Journal of nanoscience and nanotechnology. 2013. 13: 4752-4758.
20.Yao SL, Liu X, Wang XM*, et al. Directing neural stem cell fate with biomaterial parameters for injured brain regeneration. Progress in Natural Science: Materials International. 2013, 23(2), 103-112.
21.Liu X, He J, Zhang SM, Wang XM*, Liu HY, and Cui FZ. The fate of adipose stem cells controlled by surface chemistry. Journal of Tissue Engineering and Regen Med. 2013, 7(2): 112-117.
22.Lian XJ, Liu HY, Wang XM*, et al. Antibacterial and biocompatible properties of vancomycin-loaded nano-hydroxyapatite/collagen/poly (lactic acid) bone substitute (VCM/nHAC/PLA). Progress in Natural Science-Materials International. 2013. 23(6): 549-556.
23.Liu X, Wang XM*, Horii A, Wang XJ, Qiao L, Zhang SG, and Cui FZ. In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane. Nanoscale. 2012, 4 (8), 2720-2727.
24.Wang XM*, He J, Wang Y, and Cui FZ. Hyaluronic acid-based scaffold for central neural tissue engineering. Interface Focus. 2012, 2, 278-291.
25.Deng H#, Wang XM#, Du C, et al. Combined effect of ion concentration and functional groups on the surface chemistry modulated CaCO3 crystallization. CrystEngComm. 2012, 14, 6647-6653.
26.Liu ZX#, Wang XM#, Wang Q, et al. Evolution of calcium phosphate crystallization on three functional group surfaces with the same surface density. CrystEngComm. 2012, 14, 6695-6701.
27.He J, Wang XM*, Sepctor M, and Cui FZ. Scaffolds for central nervous system regeneration. Frontiers of Materials Science. 2012, 6(1): 1-25.
28.Wang Q, Wang XM*, Tian LL, Cheng ZJ, and Cui FZ. In situ remineralization of partially demineralized human dentine mediated by a biomimetic non-collagen peptide. Soft Matter. 2011, 7, 9673-9680.
29.Wang XM*, Qiao L, and Horii A. Screening of functionalized self-assembling peptide nanofiber scaffolds with angiogenic activity for endothelial cell growth. Progress in Natural Science: Materials International. 2011, 21, 111-116.
30.Chen ZJ, Wang Q, Wang XM*, Cui FZ, Ge J, Chen D, and Tian LL. Enamel Distribution, Structure and Mechanical Alterations in col1-caPPR Mice Molar. Archives of Oral Biology. 2011, 56, 1020-1026.