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Yu Rao

  Yu Rao
Associate Professor

PhD, Principal Investigator

Professional Positions:

2010-present, Principal Investigator, School of Medicine of Tsinghua University, China

2007-2010, Postdoc. Organic Chemistry, Memorial Sloan-Kettering Cancer Center & Columbia University, USA, mentor: Prof. Samuel. J. Danishefsky


2002-2007, PhD. Organic Chemistry, Complex Carbohydrate Research Center, Department of Chemistry, University of Georgia, USA, mentor: Prof. Geert-Jan Boons

1999-2002, M.S. Medicinal chemistry, Shenyang Pharmaceutical University, Shenyang, China, 2002, mentor: Prof. Ji-xiang Chen

1995-1999, B.S. Medicinal Chemistry, Shandong Medical University, Jinan, China; 1999.

Research Interests:

Developing new highly efficient synthetic methodology for constructing important heterocycles and pharmaceutical intermediates

Synthesis of bioactive compounds for potential therapeutic application and related chemical bioligy studies


1.G. Shan, X. Sun, Q. Xia and Y. Rao.* “A Facile Synthesis of Substituted 2-Alkylquinolines Through [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at Room Temperature”. Org. Lett. 2011, 13,(ASAP, DOI: 10.1021/ol202334s)

2.J. Hu, Y. Cheng, Y. Yang and Y. Rao.* “A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N–N bond formation under mild conditions ”. Chem. Commun., 2011, 47, 10133-10135.

3.G. Shan, P. Liu and Y. Rao.* “A New Synthesis of Pyrazoles through Lewis Acid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines”. Org. Lett. 2011, 13, 1746-1749. (*corresponding author)

4.Y. Rao, X. Li, P. Nagorny, J. Hayashida, S. J Danishefsky. “A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson’s Reagent“.  Tetrahedron Lett. 2009, 50, 6684-6686.

5.Y. Rao, X. Li, S. J Danishefsky. “Thio FCMA Intermediates as Strong Acyl Donors: A General Solution to the Formation of Complex Amide Bonds“. J. Am. Chem. Soc. 2009, 131, 12924-12926.

6.Yu Rao, Therese Buskas, Anathea Albert, Malcolm A. O'Neill, Michael G. Hahn, Geert-Jan Boons. “Synthesis and Immunological Properties of a Tetrasaccharide Portion of the B Side Chain of Rhamnogalacturonan II (RG-II)” Chembiochem, 2008, 9, 381-388.

7.Yu Rao, Geert-Jan Boons, “A Highly Convergent Chemical Synthesis of Conformational Epitopes of Rhamnogalacturonan II”. Angew. Chem. Int. Ed. 2007, 46, 6148-6151.

8.X. Zhu, S. Kawatkar, Y. Rao, and G .J. Boons. “A practical approach for the stereoselective introduction of β-arabinofuranosides“. J. Am. Chem. Soc. 2006, 128, 11948-11957.

9.Y. Rao, A. Venot, E.E. Swayze, R.H. Griffey and G. J. Boons. “Trisaccharide mimetics of the aminoglycoside antibiotic neomycin“. Org. Biomol. Chem. 2006, 4, 1328-1337.

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