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Yu Rao

  Yu Rao
Associate Professor
     

PhD, Principal Investigator

Professional Positions:

2010-present, Principal Investigator, School of Medicine of Tsinghua University, China

2007-2010, Postdoc. Organic Chemistry, Memorial Sloan-Kettering Cancer Center & Columbia University, USA, mentor: Prof. Samuel. J. Danishefsky

Education:

2002-2007, PhD. Organic Chemistry, Complex Carbohydrate Research Center, Department of Chemistry, University of Georgia, USA, mentor: Prof. Geert-Jan Boons

1999-2002, M.S. Medicinal chemistry, Shenyang Pharmaceutical University, Shenyang, China, 2002, mentor: Prof. Ji-xiang Chen

1995-1999, B.S. Medicinal Chemistry, Shandong Medical University, Jinan, China; 1999.

Research Interests:

Developing new highly efficient synthetic methodology for constructing important heterocycles and pharmaceutical intermediates

Synthesis of bioactive compounds for potential therapeutic application and related chemical bioligy studies

Publications:

1.G. Shan, X. Sun, Q. Xia and Y. Rao.* “A Facile Synthesis of Substituted 2-Alkylquinolines Through [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at Room Temperature”. Org. Lett. 2011, 13,(ASAP, DOI: 10.1021/ol202334s)

2.J. Hu, Y. Cheng, Y. Yang and Y. Rao.* “A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N–N bond formation under mild conditions ”. Chem. Commun., 2011, 47, 10133-10135.

3.G. Shan, P. Liu and Y. Rao.* “A New Synthesis of Pyrazoles through Lewis Acid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines”. Org. Lett. 2011, 13, 1746-1749. (*corresponding author)

4.Y. Rao, X. Li, P. Nagorny, J. Hayashida, S. J Danishefsky. “A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson’s Reagent“.  Tetrahedron Lett. 2009, 50, 6684-6686.

5.Y. Rao, X. Li, S. J Danishefsky. “Thio FCMA Intermediates as Strong Acyl Donors: A General Solution to the Formation of Complex Amide Bonds“. J. Am. Chem. Soc. 2009, 131, 12924-12926.

6.Yu Rao, Therese Buskas, Anathea Albert, Malcolm A. O'Neill, Michael G. Hahn, Geert-Jan Boons. “Synthesis and Immunological Properties of a Tetrasaccharide Portion of the B Side Chain of Rhamnogalacturonan II (RG-II)” Chembiochem, 2008, 9, 381-388.

7.Yu Rao, Geert-Jan Boons, “A Highly Convergent Chemical Synthesis of Conformational Epitopes of Rhamnogalacturonan II”. Angew. Chem. Int. Ed. 2007, 46, 6148-6151.

8.X. Zhu, S. Kawatkar, Y. Rao, and G .J. Boons. “A practical approach for the stereoselective introduction of β-arabinofuranosides“. J. Am. Chem. Soc. 2006, 128, 11948-11957.

9.Y. Rao, A. Venot, E.E. Swayze, R.H. Griffey and G. J. Boons. “Trisaccharide mimetics of the aminoglycoside antibiotic neomycin“. Org. Biomol. Chem. 2006, 4, 1328-1337.

Contact info:

Office:+86-10-62782025

Email:yrao@mail.tsinghua.edu.cn