NAME: ZHAO, LingYun
TITLE:  Assistant Professor
SCHOOL/DEPARTMENT:  Engineering Physics
TELEPHONE #: 13699268273
FAX #: 010-62796784
E-MAIL ADDRESS: lyzhao@tsinghua.edu.cn
 
Research and Teaching Interest
Medical Physics, Biomaterials and Nanomedicine
 
Education/Training

Dates of Enrollment
Institution
 
Field of Study
Degree
1991.09~1995.07
Tianjin University
Chem Engr
B.S
1995.09~1997.09
Tianjin University
Biochem Engr
M.S
1999.09~2004.08
National University of Singapore (NUS)
Biomed Engr
Ph.D.

 
Positions and Employment
2004.11 ~2006.07      Research Fellow, Chemotherapeutic Engineering Lab; NUS;
2008.01 ~2010.3        Postdoctoral Fellow, Tsinghua University
2010.04 ~                  Research Associate, Tsinghua University
 
Other Relevant Experiences and Professional Memberships
2008.01~      HuaTsing Haolian R&D Center for Medical Technology, R&D Consultant
  
Selected Peer-Reviewed Publications (Last 5 Years)
Journal Papers
1. LY Zhao and SS Feng
Effects of cholesterol component on molecular interactions between paclitaxel and phospholipid within the lipid monolayer at the air–water interface
Journal of Colloid and Interface Science, 300, 314-326, 2006
2. SS Feng, WT Zeng, YT Lim, LY Zhao, KY Win, R Oakley, ST Teoh, RCH Lee, SR Pan
Vitamin E TPGS emulsified poly(lactic-co-glycolic acid) nanoparticles for treatment and Prevention of cardiovascular restenosis
Nanomedicine, 3,333-344, 2007
3. SS Feng, LY Zhao, ZP Zhang, KY Win, YC Dong, Gajadhar Bhakta and Shu Chien
Chemotherapeutic Engineering: Vitamin E TPGS-Emulsified Nanoparticles of Biodegradable Polymers Realized Sustainable Paclitaxel Chemotherapy for 168 Hours in Vivo 
Chemical Engineering Science, 62:6641-6648, 2007
4. LY Zhao, SS Feng, N Kocherginsky and I Kostetski
DSC and EPR investigations on effects of cholesterol component on molecular interactions between paclitaxel and phospholipid within lipid bilayer membrane
International Journal of Pharmaceutics, 338, 258-66, 2007
5. LY Zhao, XY Xu, XC Dai, XW Wang, XF Wang and JT Tang
Fabrication, Characterization and In-vitro Cytotoxicity of Magnetic Nanoparticles Composite Sustainable Polymeric Film for Multi-functional Medical Application
Proc. of SPIE, 7493:74934E1-7, 2009
6.YY Zhang, W Zhang, CY Geng, TJ Lin, XW Wang, LY Zhao, JT Tang
Thermal ablation versus conventional regional hyperthermia has greater anti-tumor activity against melanoma in mice by upregulating CD4(+) cells and enhancing IL-2 secretion
Progress in Natural Science, 19 (12): 1699-1704, 2009
7. LH Du, JM Zhou, XW Wang, L Sheng, GH Wang, XX Xie, GQ Xu, LY Zhao, YP Liao,JT Tang 
Effect of local hyperthermia induced by nanometer magnetic fluid on the rabbit VX2 liver tumor model
Progress in Natural Science, 19 (12): 1705-1712, 2009
8. JM Zhou, N Li, QS Xia, LH Du, XWWang, LY Zhao, XF Wang, JTTang
Hyperthermia by a nitinol stent in an alternating magnetic field: Safety and feasibility in rabbit esophageal cancer
Progress in Natural Science, 19 (12): 1713-1719 ,2009
9. LY Zhao and SS Feng
Enhanced Oral Paclitaxel Bioavailability with vitamin E-TPGS Emulsified Biodegradable Nanoparticles: in vitro and in vivo Studies
Journal of Pharmaceutical Science, minor revision, DOI 10.1002/jps.22113, 2010
10.FP Gao, YY Cai, J Zhou, XX Xie, WW Ouyang, YH Zhang, XF Wang , XD Zhang, XW Wang, LY Zhao, JT Tang,
Pullulan Acetate Coated Magnetite Nanoparticles for Hyper-Thermia: Preparation, Characterization and In Vitro Experiments
Nano Research, 3 (1): 23-31,2010
11. LY Zhao, B Yang, XC Dai, XW Wang, JT Tang
Amino-coated Magnetic Nanoparticles with Albumin Protein for Nanothermotherapy
Journal of Nanoscience and Nanotechnology, doi:10.1166/jnn.2010.2820, 2010
12. LY Zhao,JT Tang ,SS Feng
Nanothermotherapy by High Performance Magnetic Nanoparticles: Current Status and Perspectives
Nanomedicine, In Press
  
Conference Proceedings
LY Zhao, W Jiang, YJ Jin, XW Wang, XF Wang and JT Tang
Application of Carbonyl Iron Powder as a Novel Mediator for Arterial Embolization Hyperthermia—Feasibility Study (Oral Presentation)
World Congress on Medical Physics and Biomedical Engineering 2009, Munich, 7-12, Sept 2009
 
Book Chapters & Edited Book
Zhao LY (2009) “Development and Progress in the Whole-body Applicator of Alternative Magnetic Field for Cancer Treatment” in Magnetic Mediated Hyperthermia for Cancer Treatment, Tang JT (Ed),Beijing, People’s Medical Publishing House
Zhao LY (Associate Editor), Magnetic Biomaterials (2010), Beijing, Tsinghua University Press
Zhao LY (2010) “Cancer Nanotechnology” in Overview ofClinical Oncology, Tang JT (Ed) Beijing, Tsinghua University Press.
Zhao LY (2010) “Micro-Scaled Biomaterials for Magnetic Mediated Hyperthermia” in Hyperthermia Biology for Cancer Treatment, Tang JT (Ed),Beijing, People’s Medical Publishing House
 
Research Support
Arterial Embolization Hyperthermia Mediated by Novel Magnetic-agent for Liver Tumor Treatment (PI)
Supported by supported by the National Natural Science Foundation of China
 
Effect of Stent-Magnetic Hyperthermia on Human Ephogeal Cancer Cell EC-109 and Safety Evaluation (PI)
Supported by China Postdocotoral Science Foundation; First Prize
 
Investigation on the Prevention and Treatment of Restenosis after PTCA by Heating the Stent under AC Magnetic Field. (PI)
Supported by China Postdocotoral Science Foundation; Special Aid
      
Preparation and Characterization of Magnetic Nanoparticle Composite Sustainable Polymeric Film for Medical Application (PI)
Supported by Tsinghua University;
 
Anti-CEA Labeled Magnetic Cationic Liposome Loaded with Paclitaxel for Targeted Chemothermotherapy (PI)
Supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education;
      
 
Courses Taught (Last 5 Years)
Overview of Clinical Oncology, Compulsory Course for Postgraduate, 40 Attendance,
Responsible for 2 modulus (32 modulus in total for the course)
Recent Graduate Training Experience (Last 5 Years)
Students under supervision:
PhD Candidate: Mr. Liu,JiaYi and Miss Li DanYe (Medical Physicis)
Master Candidate: Miss Huo MeiJun (Biomaterials) , Miss Wang YuYing (Biomaterials), Miss Yu HaiXia (Medical Physics) and Miss Zheng YaJing (Nanomedicine)
 
Graduated Students over the last five years:

Name
Year of graduation
Title of thesis
Degree
Xu,GuoQuan
2008.9
Anticancer Effect of B16 Malignant Melanoma in C57BL/6 Mice by Hyperthermia
Master
Liu,Kai
2008.9
Effect of Hyperthermia on Human Tongue Squamous Carcinoma Cells TCA8113
Master
Xu,Na
2009.7
Thermochemotherapy by Magnetic Fluids Combined with Paclitaxel on Human Cervical Cancer Cells
Master
Dai,XiaoChen
2009.7
Preparation of the Targeted Magnetic Nanoparticles for Cancer Hyperthermia
Master
Wang,Rui
2009.7
Effects of Electromagnetic Fields on Human Squamous Tongue Cancer Cells
Master
Lei,FengLin
2009.7
Investigation on Thermal Dosimetry and Dose-Effect Relationship for Human Cervical Carcinoma Hela cells
Master
Jiang,Wei
2009.7
Feasibility Study of Carbonyl Iron Powder as a Novel Mediator of Arterial Embolization Hyperthermia for Liver Cancer Treatment
Master
Zhang,ChangQing
2009.7
Magnetic Hyperthermia by Targeted Magnetic Nanoparticles for EV71 Infection
Master
Shi,HuanHuan
2010.7
The Feasibility of Magnetic Stent Heating for Restenosis Prevention and Treatment After PTCA
Master
Yang,Bing
2010.7
Thermochemotherapy Mediated by Nanocomposite Particles for Magnetic Hyperthermia and Drug Sustained Release—In vitro and In vivo Investigation
Master
Yan,Yan
2010.7
Bi-functional Magnetic Nano-Drug for Cancer Hyperthermia and Sustained Drug Release
Master
Xu,XiaoYu
2010.7
Fabrication, Characterization and In-vitro Cytotoxicity of Magnetic Nanoparticles Composite Sustainable Polymeric Film for Multi-functional Medical Application
Master

 

Honors And Awards