童爱军  教授,博士生导师

联系地址: 清华大学理学院分析中心4314房间

邮政编码: 100084

办公电话: 010-62787682, 010-62782759

电子邮件: tongaj@mail.tsinghua.edu.cn

讲授的课程:《分析化学》、《仪器分析》

教育背景

1983年7月本科毕业。

1985年3月-1986年1月在东北师范大学留日预备校学习日语。

1986年7月公派赴日本留学。

1989年3月、1992年3月先后在日本东京明星大学获理学硕士、博士学位。

工作履历

1992年4月起在清华大学化学系工作。

1999年4月-10月作为日本学术振兴会客座研究员在日本东北大学化学系从事糖分子的荧光超分子受体研究。

研究领域

1.各类光学探针,包括紫外-可见吸光探针、荧光、磷光探针的设计合成及其分析应用

2.聚集荧光增强型有机染料的设计合成

3.基于功能DNA的化学传感

研究概况

一、 聚集荧光增强型有机染料

聚集荧光增强型有机染料是一类在聚集态有很强的荧光,而在溶液等分散状态下荧光较弱的分子。因其具有很好的薄膜/固态荧光性质,预期在有机发光二极管(OLED)和激光研究领域具有非常广阔的研究前景。本课题组设计合成了多种分子结构简单、制备成本低廉、性能优良的基于N-N单键或C-N单键旋转的水杨醛腙或水杨醛胺类聚集荧光增强型分子,以其作为小分子荧光探针,实现了水溶液以及细胞内金属离子、pH、肼、蛋白质、以及其他具有重要生物、环境作用分析物的高灵敏度高选择性荧光增强型分析检测及成像分析。进一步,我们还发现了取代基与AIEE染料颜色和形貌的影响规律,获得了具有压致、热致变色、光波导性能以及液晶特性的多种性能优异的发光材料。                            

Salicylaldehyde azine 

Aniline substituted salicylaldehyde Schiff base

近期代表性论文:

J. Org. Chem., 2009, 74(5), 2163; J. Phys. Chem. C, 2011, 115(29), 14353; Analyst, 2010, 135(5), 1098

 

二、 基于络合或化学反应的金属离子荧光探针

设计合成了多种络合型或反应型金属离子荧光探针、水溶液中的pH荧光探针,建立了高选择性高灵敏度金属离子的荧光增强型、比率型检测方法和细胞成像方法。

近期代表性论文:

J. Mater. Chem., 2011, 21(35), 13470; Chem.Comm., 2010, 46(19), 3363; Talanta, 2010, 80(5), 1952; Anal. Chim. Acta, 2008, 619(1), 75; Talanta, 2008, 74(5), 1148; Tetrahedron Lett., 2008, 49(32), 4697; Anal. Chim. Acta, 2007, 597(1), 97; Anal. Chim. Acta, 2007, 581(1), 132; Org. Lett., 2006, 8 (13), 2863; Org. Lett., 2006, 8 (8), 1549.

 

三、非标记的功能脱氧核糖核酸传感体系

与美国伊利诺伊大学香槟分校Yi Lu 教授课题组合作,在DNA链中引入abasic site位点,建立了非标记的功能脱氧核糖核酸传感系统,实现了非荧光标记法检测溶液中浓度不低于4 nM的环境污染物铅离子或3.4µM腺嘌呤核苷酸的特异性检测(J. Am. Chem. Soc. 2009);建立了以分子信标代替DNA酶的底物,用非标记催化分子信标的方法检测铅离子和腺嘌呤核苷酸(Anal. Chem. 2012),进一步降低了背景信号,提高了测定灵敏度。

近期代表性论文:

Anal. Chem., 2012, 84 (6), 2916;J. Am. Chem. Soc., 2009, 131(42), 15352

 

 

学术成果

 

 

 发表论著:

 

1. Song PS; Xiang Y; Xing H; Zhou ZJ; Tong AJ; Lu Y, Label-free Catalytic and Molecular Beacon Containing an Abasic Site for Sensitive Fluorescent Detection of Small Inorganic and Organic Molecules, Analytical Chemistry, 2012, 84, 2916-2922

2. Chen XT; Wei RR; Xiang Y; Zhou ZJ; Li K; Song PS; Tong AJ, Organic Crystalline Solids Response to Piezo/thermo Stimulus: Donor-Acceptor (D-A) Attached Salicylaldehyde Azine Derivatives, Journal of Physical Chemistry C, 2011, 115(29), 14353-14359

3. Song PS; Chen XT; Xiang Y; Huang L; Zhou ZJ; Wei RR; Tong AJ, A ratiometric fluorescent pH probe based on aggregation-induced emission enhancement and its application in live-cell imaging, Journal of Materials Chemistry, 2011, 21(35), 13470-13475

4. Li N; Xiang Y; Tong AJ, Highly sensitive and selective "turn-on" fluorescent chemodosimeter for Cu2+ in water via Cu(2+)-promoted hydrolysis of lactone moiety in coumarin, Chemical Communications, 2010, 46(19), 3363-3365

5. Chen XT; Xiang Y; Tong AJ, Facile, sensitive and selective fluorescence turn-on detection of HSA/BSA in aqueous solution utilizing 2,4-dihydroxyl-3-iodo salicylaldehyde azine, Talanta, 2010, 80(5), 1952-1958

6. Chen XT; Xiang Y; Li N; Song PS; Tong AJ, Fluorescence turn-on detection of protamine based on aggregation-induced emission enhancement characteristics of 4-(6 '-carboxyl)hexyloxysalicyl aldehyde azine, Analyst, 2010, 135(5), 1098-1105

7. Xiang Y; Tong AJ; Lu Y, Abasic Site-Containing DNAzyme and Aptamer for Label-Free Fluorescent Detection of Pb2+ and Adenosine with High Sensitivity, Selectivity, and Tunable Dynamic Range, Journal of the American Chemical Society, 2009, 131(42), 15352-15357

8. Tang WX; Xiang Y; Tong AJ, Salicylaldehyde Azines as Fluorophores of Aggregation-Induced Emission Enhancement Characteristics, Journal of Organic Chemistry, 2009, 74(5), 2163-2166

9. Li ZF; Xiang Y; Tong AJ, Ratiometric chemosensor for fluorescent determination of Zn2+ in aqueous ethanol, Analytica Chimica Acta, 2008, 619(1), 75-80

10. Xiang Y; Li N; Chen XT; Tong AJ, Highly sensitive and selective optical chemosensor for determination of Cu2+ in aqueous solution, Talanta,, 2008, 74(5), 1148-1153

11. Chen XT; Li ZF; Xiang Y; Tong AJ, Salicylaldehyde fluorescein hydrazone: A colorimetric logic chemosensor for pH and Cu(II), Tetrahedron Letters, 2008, 49(32), 4697-4700

12. Li N; Mei L; Xiang Y; Tong AJ, Nishizawa S; Teramae N, Fluorescence detection of single-nucleotide polymorphisms with two simple and low cost methods: A double-DNA-probe method and a bulge form method, Analytica Chimica Acta, 2007, 597(1), 97-102

13. Xiang Y; Mei L; Li N; Tong AJ, Sensitive and selective spectrofluorimetric determination of chromium(VI) in water by fluorescence enhancement, Analytica Chimica Acta, 2007, 581(1), 132-136

14. Xiang Y; Tong AJ; Jin PY; Ju Y, New fluorescent rhodamine hydrazone chemosensor for Cu(II) with high selectivity and sensitivity, Organic Letters, 2006, 8 (13), 2863-2866

15. Xiang Y; Tong AJ, A new rhodamine-based chemosensor exhibiting selective Fe-III-amplified fluorescence, Organic Letters, 2006, 8 (8), 1549-1552